MOTS-c 40mg
€1.00
Peptide Profile
MOTS-c — A Mitochondrial powerhouse for metabolism, performance & healthy aging. Unlock cleaner energy, more consistent glucose management, and enhanced stamina. MOTS-c is a peptide encoded by the mitochondria that activates AMPK, optimizes energy usage, enhances insulin sensitivity, and helps you train harder while recovering faster—while simultaneously reducing inflammation and cellular stress responses associated with aging.
Peptide Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
CAS Number: 1627580-64-6
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂ (free peptide)
Primary Function: Regulator of metabolism; AMPK activation; mimicking exercise effects
Mechanism of Action:
In skeletal muscle, MOTS-c inhibits the folate/purine pathway → resulting in increased endogenous AICAR → leading to AMPK activation → which improves glucose uptake and fat oxidation.
In stressful situations, MOTS-c moves to the nucleus and interacts with stress-response programs (including NRF2-linked antioxidant genes), helping to coordinate resilience.
Key Features & Benefits
Enhances insulin sensitivity and proper glucose handling
Increases training capacity and muscular performance
Facilitates fat utilization and supports favorable body composition
Boosts mitochondrial efficiency and resilience against cellular stress
Offers broad support for healthy aging through AMPK/NRF2 pathways
Who Benefits Most:
Athletes & highly active individuals looking for endurance, work capacity, and recovery
People focused on body recomposition and metabolic wellness
Longevity enthusiasts optimizing energy at the cellular level and enhancing stress defenses
Effects on Key Areas:
Blood sugar & insulin: Enhances insulin sensitivity and uptake mechanisms
Endurance & performance: Boosts physical performance in animal studies; MOTS-c levels increase with human exercise
Body composition: Encourages fat oxidation and improved metabolic signaling
Recovery & inflammation: Activates NRF2-mediated antioxidant responses
Cellular/mitochondrial function: Supports proteostasis and adaptability to stress
Discovered by researchers at the University of Southern California (Lee, Cohen, et al.), MOTS-c is a 16-amino-acid microprotein encoded by mitochondrial DNA. It acts as a mitokine—a mitochondria-to-nucleus signal that reprograms metabolism for performance and resilience. Landmark work in Cell Metabolism (2015) mapped its AMPK-centric mechanism; later studies showed nuclear translocation during stress and broad regulation of gene networks tied to antioxidant defense and recovery.
Enhanced training capacity and endurance
Improved metabolism—nutrient distribution and fat burning through AMPK
Support for insulin sensitivity and better glycemic control
Reduction of inflammation and oxidative stress
Mitochondrial performance and adaptation to stress for healthy aging
Cell Metabolism (2015) identified MOTS-c; it demonstrated enhanced insulin sensitivity, improved glucose uptake, and offered protection against diet-induced metabolic dysfunction in mice through folate → AICAR → AMPK signaling.
Cell Metabolism (2018) revealed nuclear translocation during metabolic stress and the coordination of antioxidant/stress-response genes.
Nature Communications (2021): Exogenous MOTS-c improved physical capacity and healthspan indicators in mice; in humans, MOTS-c levels—both circulating and intramuscular—rise with acute exercise (exercise-induced). This was not a trial involving injected MOTS-c in humans.
Further human data indicate that MOTS-c levels are associated with training status and vary with structured exercise programs.
Reviews summarize evidence that MOTS-c may decrease insulin resistance, enhance muscle function, and influence aging pathways, based mostly on animal and cellular studies, alongside an increasing amount of human observational data.
No direct human trials have demonstrated benefits in cognition or sleep following MOTS-c administration. Some rodent and in-vitro studies indicate potential neuroprotective effects or memory enhancements using brain-targeted MOTS-c analogs, but translating these findings to humans is still uncertain. Observational studies associate lower circulating levels of MOTS-c with conditions such as obstructive sleep apnea, though this is correlation—not evidence that providing MOTS-c improves sleep.
If you’ve come across claims from Nature Communications or Cell Metabolism suggesting that human cognition, sleep, or athletic endurance improved from injected MOTS-c, those are misinterpretations. The improvements in endurance were observed in mice, while human data primarily reflected exercise-induced variations in endogenous MOTS-c levels.
Generally well-tolerated in preclinical models. Feedback from users (along with guidance from peptide vendors) indicates that mild, temporary effects may occur when they do:
Headache
Nausea or mild gastrointestinal discomfort
Temporary redness or irritation at the injection site
It's important to avoid excessive dosing and to adhere to sensible cycling. Comprehensive human safety data remain limited.
Support for endurance: Preclinical studies indicate increased running ability and resistance to fatigue; training in athletes elevates MOTS-c, hinting at a possible synergy with intense training sessions.
Efficiency in metabolism: The activation of AMPK promotes the switching between carbohydrates and fats for prolonged activities and more "efficient" energy use.
Resilience and recovery: Nuclear signaling and NRF2 pathways assist in managing oxidative stress following rigorous training.
Note on anti-doping: The use of exogenous MOTS-c is banned for athletes under anti-doping regulations; always verify the regulations specific to your sport.
What is MOTS-c?
A 16-amino acid peptide encoded by mitochondria that stimulates AMPK, enhances metabolic signaling, and is triggered by exercise.Key benefits?
Improved metabolic efficiency, support for insulin sensitivity, enhanced endurance (in animals), resilience against cellular stress, and pathways for healthy aging.Who can use it?
Individuals who are active and those seeking body recomposition or longevity who desire performance, recovery, and metabolic support—considering personal health factors and sport regulations.How do I administer it?
By subcutaneous injection (in the abdomen or thigh); hold for 10 seconds before withdrawing; rotate injection sites.Is it legal for sport?
Exogenous MOTS-c is banned by anti-doping regulations—consult with your federation.
MOTS-c synchronizes metabolism with performance: enhanced energy signaling, improved fuel utilization, and robust recovery from stress—along with healthy-aging pathways that assist you in feeling (and performing) younger. Develop more endurance, sustain energy longer, and recover more quickly.